Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes
نویسندگان
چکیده
منابع مشابه
HLA Class I and Genetic Susceptibility to Type 1 Diabetes
OBJECTIVE We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies wer...
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Approximately 50% of the genetic risk for type 1 diabetes is attributable to the HLA region. We evaluated associations between candidate genes outside the HLA region-INS, cytotoxic T-lymphocyte-associated antigen (CTLA)-4, interleukin (IL)-4, IL-4R, and IL-13 and islet autoimmunity among children participating in the Diabetes Autoimmunity Study in the Young (DAISY). Children with persistent isl...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2021
ISSN: 1664-8021
DOI: 10.3389/fgene.2021.683946